Accelerating Medical Practice.

MC-RAN-11CThe patent pending MARROW CELLUTION™ Bone Marrow Harvesting Systems overcome the limitations of a traditional bone marrow needle by allowing the user to aspirate in a measured and controlled manner over a large geography inside the marrow space, while restricting peripheral blood infiltration. The result is a bone marrow harvest that is so rich in key stem and progenitor cells that the aspirate no longer has to be manipulated through centrifugation prior to application.

 

Key Benefits:

  • Reduce the Cost of Utilizing Biologics: The Marrow Cellution™ System delivers a regenerative solution at a reduced cost compared to the industry leading solutions. To investigate the cost benefits of smarter engineering.
  • Minimize O/R Time: Centrifugation systems typically require 20 minutes or more of spin time during the surgical procedure, not to mention the additional personnel (i.e. perfusion) and support time needed for preparation and cleanup of the equipment.
  • Minimize Sterility Challenges: Centrifugation systems require passing the BMA off the sterile field for processing and back on for implantation. The Marrow Cellution™ System eliminates the additional steps where infection concerns must be managed.
  • Minimize Sample Waste: Centrifugation systems typically discard 80% of the aspirate due to the high levels of peripheral blood. Worse, significant numbers of the desired cells (approx. 40%) are discarded because as these cells increase in density prior to division, they are processed into the undesired red cell centrifuge component and thus discarded, substantially limiting the regenerative potential of the resulting sample.
  • Minimize Use of Anti-Coagulants: Centrifugation systems require at least 10% dilution by volume for the addition of anti-coagulant to allow the sample to separate, and also require another 10% dilution in the form of a neutralizing agent such as thrombin and calcium chloride in order for the marrow to clot in the graft. The Marrow Cellution™ System eliminates these requirements.
  • Eliminate the Need to Filter: Protocols require the marrow to be filtered prior to centrifugation. Cells bound within a cell aggregate can be delivered to the patient when mixed with graft material or injected. This is not the case when aggregates are filtered out prior to centrifugation. Filtering takes additional time, but more importantly, filtering reduces regenerative potential.

Marrow Cellutions Outperforms Other Leading BMAC Needles on the Market

Research has demonstrated that the number of fibroblast-like colony forming units (CFU-f) in a graft is positively correlated with clinical outcomes. [2,3]. Cells capable of forming a CFU-f are found in marrow but not in blood and therefore are an indication of the number of early stage stem and progenitor cells present in a biologic. Several systems are available for harvesting autologous bone marrow aspirate and optionally centrifuging it to further concentrate cells, via volume reduction, to treat local bone defects [1,2,3].

REFERENCES
1. Connolly J. et al. JBJS 1989;71: 684-91.
2. Hernigou P. et al. JBJS 2006; 88 Suppl 1: 322-27.
3. Hernigou P. et al. JBJS 2005; 87: 1430-7.
4. Hedge V. et al. Journal of Orthopedic Trauma 2014; vol 28; issue 10; p 591-598


MARROW CELLUTION™ IS AVAILABLE IN TWO STYLES AND MULTIPLE SIZES; ALL UTILIZING THE SAME PATENT PENDING TECHNOLOGY TO OPTIMIZE BONE MARROW ASPIRATION.

For Bone Marrow Aspirate

Catalog # Part # Description
MC-RAN-13C 74291-01M 13 Gauge x 3.5″ Introducer Needle
13 Gauge Blunt Stylet
17 Gauge Aspiration Cannula
10 mL Syringe
MC-RAN-13CSTS 74291-02M 13 Gauge x 4.5″ Introducer Needle
13 Gauge Blunt Stylet
17 Gauge Aspiration Cannula
10 mL Syringe
MC-RAN-11C 74219-06M 11 Gauge x 3.5″ Introducer Needle
11 Gauge Blunt Stylet
14 Gauge Aspiration Cannula
10 mL Syringe
MC-RAN-11CSTS
(For Obese Patients)
74219-07M 11 Gauge x 4.5″ Introducer Needle
11 Gauge Blunt Stylet
14 Gauge Aspiration Cannula
10 mL Syringe

For Bone Marrow Aspirate + Percutaneous cancellous bone harvesting

Catalog # Part # Description
MC-RAN-13A 74293-01M Includes all MC-RAN-13C components
8 Gauge x 4″ Swaged Tip Introducer Needle
Measurement Probe
Cancellous Bone Dowel Extraction Tool
MC-RAN-13ASTS 74293-02M Includes all MC-RAN-13CSTS components
8 Gauge x 6″ Swaged Tip Introducer Needle
Measurement Probe
Cancellous Bone Dowel Extraction Tool
MC-RAN-8C 74266-01M Includes all MC-RAN-11C components
8 Gauge x 4″ Swaged Tip Introducer Needle
Measurement Probe
Cancellous Bone Dowel Extraction Tool
MC-RAN-8CSTS
(For Obese Patients)
74266-04M Includes all MC-RAN-11CSTS components
8 Gauge x 6″ Swaged Tip Introducer Needle
Measurement Probe
Cancellous Bone Extraction Tool

“My patients outcomes have improved greatly and quicker since I started using the Marrow Cellution bone marrow needle.” — Anne Truong (Rehabilitation Med Physicians) www.truongrehab.com

“This is potentially a giant step in bone marrow processing. This needle will usher in a new age in bone marrow aspiration.” — Dr. Joseph Purita, M.D. (Orthopedic Surgeon, Boca Raton, FL)

“Hands down, the best method is the new Marrow Cellution needle. It’s a game changer. Far easier to use, only one insertion point through the PSIS (rather than multiple entry sites through the ilium), and a MUCH better stem cell yield than the traditional Jamshidi needle approach.” — Paul D. Tortland, D.O., FAOASM, RMSK (Associate Clinical Professor of Medicine, University of Connecticut School of Medicine, Fellow of the American Osteopathic Academy of Sports Medicine, Registered, Musculoskeletal Ultrasound, Team Physician, University of Hartford & Avon High School)

“For the same patient and procedure, the measured number of progenitor cells per cc in the aspirate alone was comparable to the centrifugation concentrate protocol.” — Dr. Leonel Liriano, M.D. (Prof. for Cardiology and Intensive Care at the Tech. University of Santiago (UTES))

“I am always suspicious that when we centrifuge bone marrow aspirate we might be throwing away significant aspects of the regenerative potential of biologic.” — Dr. David Harrell, Ph.D.